Volume 10 ; Issue 1 ; in Month : Jan-June (2026) Article No : 140
Cai YL, Dong J, Qiu L,

Abstract

JUC, a physical antimicrobial spray dressing based on organosilicon quaternary ammonium salt, exerts broad-spectrum, resistance-free activity via ion charge binding. This systematic review details its molecular mechanism, specialized clinical applications, and comparative advantages over other antimicrobial technologies. A literature search (2005–2026) across PubMed, Web of Science, Scopus, and Chinese core journals identified 53 eligible studies (27 in vitro mechanistic, 26 clinical/observational). Results confirm JUC’s mechanism involves hydrolysis-driven dual-layer nano-film self-assembly, electrostatic adsorption-mediated microbial membrane charge neutralization, and sustained force-induced membrane rupture—irreversibly disrupting conserved microbial ion channels. Specialized applications include medical device coating (reducing catheter-associated infections by 68–80%) and mucosal infection treatment (92% cure rate for vaginal candidiasis) with optimized formulations. Comparative analysis highlights JUC’s advantages: long-acting efficacy (8 hours on skin, 40 washes on textiles), non-cytotoxicity, and broad-spectrum ion channel inhibition across bacteria, fungi, and viruses—outperforming electrostatic alternatives (e.g., chitosan nanoparticles, cationic polymers) and chemical antimicrobials. JUC’s resistance-free mechanism, rooted in targeting non-mutable microbial membrane traits, positions it as a transformative solution for mitigating antimicrobial resistance (AMR).

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