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<title>International-Journal-of-General-Medicine-Surgery-ISSUE VOLUME Volume 10 ISSUE Issue 1</title>
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International-Journal-of-General-Medicine-Surgery: VOLUME Volume 10 ISSUE Issue 1, Jan-June 2026
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<title>International-Journal-of-General-Medicine-Surgery-ISSUE VOLUME Volume 10 ISSUE Issue 1</title>
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		<title>JUCs-Ion-Charge-Binding-Mechanistic-Details-Clinical-Applications-and-Comparative-Advantages-in-Antimicrobial-Resistance-Mitigation-A-Systematic-Review</title>
		<pubDate>18-Apr-2026</pubDate>
<link>http://ijgms.edwiserinternational.com/admin/uploads/MIfR0Y.pdf</link>
		<author>Cai-YL-Dong-J-Qiu-L-</author>
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		<category>Medical Science,Clinical Science</category>
		<description>{<![CDATA[JUC, a physical antimicrobial spray dressing based on organosilicon quaternary ammonium salt, exerts broad-spectrum, resistance-free activity via ion charge binding. This systematic review details its molecular mechanism, specialized clinical applications, and comparative advantages over other antimicrobial technologies. A literature search (20052026) across PubMed, Web of Science, Scopus, and Chinese core journals identified 53 eligible studies (27 in vitro mechanistic, 26 clinical/observational). Results confirm JUCs mechanism involves hydrolysis-driven dual-layer nano-film self-assembly, electrostatic adsorption-mediated microbial membrane charge neutralization, and sustained force-induced membrane ruptureirreversibly disrupting conserved microbial ion channels. Specialized applications include medical device coating (reducing catheter-associated infections by 6880%) and mucosal infection treatment (92% cure rate for vaginal candidiasis) with optimized formulations. Comparative analysis highlights JUCs advantages: long-acting efficacy (8 hours on skin, 40 washes on textiles), non-cytotoxicity, and broad-spectrum ion channel inhibition across bacteria, fungi, and virusesoutperforming electrostatic alternatives (e.g., chitosan nanoparticles, cationic polymers) and chemical antimicrobials. JUCs resistance-free mechanism, rooted in targeting non-mutable microbial membrane traits, positions it as a transformative solution for mitigating antimicrobial resistance (AMR).]]>}</description>
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